Fatigue-Animal models, Circadian rhythms, Animal models in research, Interleukin-1, Inflammation, Circadian, Fatigue
The main purpose behind this Honor Thesis work is to validate an animal model of fatigue. In our animal model, which will be discussed in detail later in the paper, fatigue is induced immunologically in mice through injections of interleukin-1β, a pro-inflammatory cytokine. The beginning part of this introduction will give background on interleukin-1β and its mechanisms of action, and later sections will provide background on the suprachiasmatic nucleus and how its function may be affected by interleukin-1β.
McKay-Corkum, Grace Brown, "The effects of IL-1β on sleep and circadian rhythmicity in an animal model of fatigue" (2014). Theses, Dissertations, and Projects. 70.