Publication Date

2014

Document Type

Honors Thesis

Department

Neuroscience

Keywords

Fatigue-Animal models, Circadian rhythms, Animal models in research, Interleukin-1, Inflammation, Circadian, Fatigue

Abstract

The main purpose behind this Honor Thesis work is to validate an animal model of fatigue. In our animal model, which will be discussed in detail later in the paper, fatigue is induced immunologically in mice through injections of interleukin-1β, a pro-inflammatory cytokine. The beginning part of this introduction will give background on interleukin-1β and its mechanisms of action, and later sections will provide background on the suprachiasmatic nucleus and how its function may be affected by interleukin-1β.

Language

English

Comments

59 pages : illustrations (chiefly color). Honors Project-Smith College, 2014. Includes bibliographical references (pages 53-59)

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