Document Type

Article

Publication Date

1-1-2014

Publication Title

Expert Review of Vaccines

Abstract

Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world's poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.

Keywords

Brugia malayi, computational vaccinology, EID, EpiMatrix, filarial, immunogenicity, immunoinformatics, immunomics, JanusMatrix, MHC, NTD, T cell, TCR, tregitope

Volume

14

Issue

1

First Page

21

Last Page

35

DOI

10.1586/14760584.2015.955478

ISSN

14760584

Rights

© 2015 Informa UK Ltd

Comments

Archived as published. Open access paper.

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Biology Commons

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