Tandem Intramolecular Nicholas and Pauson-Khand Reactions for the Synthesis of Tricyclic Oxygen-Containing Heterocycles

Authors

Miriam M. Quintal
Kristina D. Closser
Kevin M. Shea, Smith CollegeFollow

Document Type

Article

Publication Date

11-18-2004

Publication Title

Organic Letters

Abstract

Simple acyclic enynes can be easily converted into tricyclic ethers upon treatment with Co2(CO)8followed by Nicholas and Pauson−Khand reactions. Tricyclic [5,8,5]- and [5,7,5]-systems can be prepared in high overall yields in only seven synthetic steps.

Volume

62

Issue

6

First Page

4949

Last Page

4952

DOI

10.1021/ol0479141

Rights

“This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/doi/abs/10.1021/ol0479141

Comments

Peer reviewed accepted manuscript.

Recommended Citation

Quintal, Miriam M.; Closser, Kristina D.; and Shea, Kevin M., "Tandem Intramolecular Nicholas and Pauson-Khand Reactions for the Synthesis of Tricyclic Oxygen-Containing Heterocycles" (2004). Chemistry: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/chm_facpubs/10