Over 1 billion people worldwide are affected by Neglected Topical Diseases (NTDs). This group of pathogens encapsulates viruses, bacteria and parasites, and disproportionately affects the world’s poorest and most vulnerable communities in Africa, Asia and Latin America. Lymphatic Filariasis (LF) is an NTD caused by a parasitic nematode infection. The larvae of these filarial nematode worms are transmitted via mosquito bites and disrupt the functioning of the infected individual’s lymphatic system. LF can be caused by three types of filarial worms, Wuchereria bancrofti, Brugia malayi and Brugia timori, which are transmitted by the Culex, Anopheles and Aedes mosquito families. Symptomatic infection manifests in the form of lymphoedema and elephantiasis, in which patients experience highly debilitating and stigmatising enlargement of the limbs and genitals.
Shea, Kevin M. and Williams, Steven, "Neglected Nematodes: The Neurolenin Solution" (2021). Chemistry: Faculty Publications, Smith College, Northampton, MA.
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Originally published on Research Features website.