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Publication Date


Document Type

Honors Project




Crystallization, Cooling, Crystal whiskers, Diffraction, Cold point, Single crystal X-ray diffraction, Pharmaceutical ingredient


Pharmaceutical companies use single crystal X-ray diffraction to characterize the precise conformations of new active pharmaceutical ingredients. It is crucial to grow defect-free crystals of good quality for use in X-ray diffraction experiments. Here, I investigated a new cooling method for crystallization, called "cold point" method. By introducing a cold tip in saturated solution of an API, a temperature gradient is created. The solute will precipitate and crystallization is most likely to occur at the coldest point, which is the tip. Experiments were conducted to test this idea. A cooling device was designed and revised to create a cold tip at appropriate temperature. This cooling device was used in crystallization experiments of ascorbic acid in water. Crystals were successfully formed on the cold tip, and thus the cold point method was supported.




32 pages : color illustrations. Honors Project-Smith College, 2014. Includes bibliographical references (page 27)