To access this work you must either be on the Smith College campus OR have valid Smith login credentials.

On Campus users: To access this work if you are on campus please Select the Download button.

Off Campus users: To access this work from off campus, please select the Off-Campus button and enter your Smith username and password when prompted.

Non-Smith users: You may request this item through Interlibrary Loan at your own library.

Publication Date


Document Type

Honors Project


Biological Sciences


Apicomplexa, Phylogenomics, Chromosome mapping, Genome evolution, Apicomplexa-Phylogeny, Phylogeny, Gene mapping, Evolutionary genetics


Malaria is a pandemic, especially in developing countries, and is thus the subject of much biological research. Plasmodium falciparum, the causative agent of malaria and a member of the pathogenic clade called Apicomplexa, has been the subject of intense study. Using the completely mapped genome of P. falciparum, I developed a method that maps the phylogenetic relationship of each gene across all 14 chromosomes of P. falciparum. With these maps, I am able to identify clusters showing patterns of conservation and rates of evolution in P. falciparum. The data from this study suggest that there are more rapidly evolving genes in the genome of P. falciparum (genes that are SAR specific), especially in the telomeric regions. The results further suggest that there are few LGT events and several duplication events in the genome of P. falciparum.




45 pages : color illustrations, color map. Honors project, Smith College, 2016. Includes bibliographical references (pages 43-45)