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Publication Date


Document Type

Honors Project




Crystallization, Solvents-Properties, Polarization (Electricity), Dielectrics, Ionization constants, Solutions, Supersaturated, Polarity, Supersaturation, Dielectric constant, Solvent property


In this thesis, the effects of solvent properties on crystal formations are studied. The first section focuses on giving the reader an overview. It explains the context and the likely industrial application of the study outcome. In the second part, the author approaches the topic quantitatively by introducing the theoretical foundations for the significance of solvent selection. The reader will be able to walk through a few mathematical models that were built from previous scientific research and then get a general idea of how and why each factor matters from a mathematical perspective. To validate the mathematical prediction, experimental observations from various research labs, as well as the results obtained by the Smith College Pfizer Design team, are presented. They both demonstrate good agreements with the theoretical foundations discussed in the preceding sections. Both the theoretical discussions and the experimental interpretations have formed solid foundations for the author to design a recipe that can serve as a guideline for engineers to follow when making solvent selections before starting a crystallization. The author lists step by step recommendations which, if followed carefully, would facilitate the selection of good solvents, and ultimately optimize the formation process of good crystals. As the first step of all crystallization processes, solvent selection is critical for improving the operating efficiency. Therefore, the author is hoping that, after reading this thesis, the reader will achieve a better understanding of the following three aspects: 1) why solvent selection matters; 2) the important parameters associated with the process; 3) most importantly, a protocol to reference when making decisions.




37 pages : illustrations (some color). Honors Project-Smith College, 2014. Includes bibliographical references (pages 33-34)