Document Type
Article
Publication Date
1-1-2014
Publication Title
Expert Review of Vaccines
Abstract
Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world's poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.
Keywords
Brugia malayi, computational vaccinology, EID, EpiMatrix, filarial, immunogenicity, immunoinformatics, immunomics, JanusMatrix, MHC, NTD, T cell, TCR, tregitope
Volume
14
Issue
1
First Page
21
Last Page
35
DOI
10.1586/14760584.2015.955478
ISSN
14760584
Rights
© 2015 Informa UK Ltd
Recommended Citation
Terry, Frances E.; Moise, Leonard; Martin, Rebecca F.; Torres, Melissa; Pilotte, Nils; Williams, Steven A.; and De Groot, Anne S., "Time for T? Immunoinformatics Addresses Vaccine Design for Neglected Tropical and Emerging Infectious Diseases" (2014). Biological Sciences: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/bio_facpubs/164
Comments
Archived as published. Open access paper.