Document Type
Conference Proceeding
Publication Date
12-1-2012
Publication Title
Biochemical Society Transactions
Abstract
Pathogenic bacteria resistant to many or all antibiotics already exist. With the decline in microbiological research at pharmaceutical companies, the high rate at which resistance has evolved and spread has demanded a novel approach to addressing this critical human health issue. In the present paper, we propose a new paradigm in antibiotic discovery and development, one that applies ecological and evolutionary theory to design antimicrobial drugs that are more difficult and/or more costly to resist. In essence, we propose to simply adopt the strategies invented and applied by bacteria for hundreds of millions of years. Our research focuses on bacteriocins, powerful biological weapons, and their use as alternative therapeutics in human health. ©The Authors Journal compilation
Keywords
Antibiotic, Bacteriocin, Targeted therapeutic, Urinary tract infection (UTI)
Volume
40
Issue
6
First Page
1438
Last Page
1442
DOI
10.1042/BST20120179
ISSN
03005127
Rights
©2012 Biochemical Society.
Recommended Citation
Riley, Margaret A.; Robinson, Sandra M.; Roy, Christopher M.; Dennis, Morgan; Liu, Vivian; and Dorit, Robert, "Resistance is Futile: The Bacteriocin Model for Addressing the Antibiotic Resistance Challenge" (2012). Biological Sciences: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/bio_facpubs/227
Comments
Archived as published.