Effects of Resistance Exercise on Endothelial Progenitor Cell Mobilization in Women

Authors

Fernando Ribeiro, University of Aveiro
Ilda P. Ribeiro, University of Coimbra
Ana C. Gonçalves, University of Coimbra
Alberto J. Alves, University Institute of Maia
Elsa Melo, University of Aveiro
Raquel Fernandes, University of Aveiro
Rui Costa, University of Aveiro
Ana B. Sarmento-Ribeiro, University of Coimbra
José A. Duarte, University of Porto
Isabel M. Carreira, University of Coimbra
Sarah Witkowski, Smith CollegeFollow
José Oliveira, University of Porto

Document Type

Article

Publication Date

12-19-2017

Publication Title

Scientific Reports

Abstract

This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n = 13), 70% (n = 12) or 80% (n = 13) of one repetition maximum. Each session was comprised of three sets of 12 repetitions of four exercises: bench press, dumbbell curl, dumbbell squat, and standing dumbbell upright row. Blood was sampled at baseline and immediately, 6 hours, and 24 hours post-exercise. Circulating EPC and levels of VEGF, HIF-1α and EPO were significantly higher after exercise (P < 0.05). The change in EPCs from baseline was greatest in the 80% group (P < 0.05), reaching the highest at 6 hours post-exercise. The change in EPCs from baseline to 6 hours post-exercise was correlated with the change in VEGF (r = 0.492, P = 0.002) and HIF-1α (r = 0.388, P = 0.016). In general, a dose-response relationship was observed, with the highest exercise intensities promoting the highest increases in EPCs and angiogenic factors.

Volume

7

First Page

17880

DOI

DOI:10.1038/s41598-017-18156-6

Rights

© the authors

Comments

Archived as published.

Link to publisher version: https://www.nature.com/articles/s41598-017-18156-6

Recommended Citation

Ribeiro, Fernando; Ribeiro, Ilda P.; Gonçalves, Ana C.; Alves, Alberto J.; Melo, Elsa; Fernandes, Raquel; Costa, Rui; Sarmento-Ribeiro, Ana B.; Duarte, José A.; Carreira, Isabel M.; Witkowski, Sarah; and Oliveira, José, "Effects of Resistance Exercise on Endothelial Progenitor Cell Mobilization in Women" (2017). Exercise and Sport Studies: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/ess_facpubs/1