High-Frequency Electrically Stimulated Skeletal Muscle Contractions Increase p70^s6k Phosphorylation Independent of Known IGF-I Sensitive Signaling Pathways

Authors

Sarah Witkowski, University of Maryland School of Public HealthFollow
Richard M. Lovering, University of Maryland School of Medicine
Espen E. Spangenburg, University of Maryland School of Public Health

Document Type

Article

Publication Date

7-1-2010

Publication Title

FEBS Letters

Abstract

Insulin-like growth factor (IGF-I) is hypothesized to be a critical upstream regulator of mammalian target of rapamycin (mTOR)-regulated protein synthesis with muscle contraction. We utilized a mouse model that expresses a skeletal muscle specific dominant-negative IGF-I receptor to investigate the role of IGF-I signaling of protein synthesis in response to unilateral lengthening contractions (10 sets, 6 repetitions, 100. Hz) at 0 and 3. h following the stimulus. Our results indicate that one session of high frequency muscle contractions can activate mTOR signaling independent of signaling components directly downstream of the receptor.

Keywords

Hypertrophy, IGF-I receptor mutant mouse, Insulin-like growth factor I

Volume

584

Issue

13

First Page

2891

Last Page

2895

DOI

10.1016/j.febslet.2010.05.003

ISSN

00145793

Rights

© 2010 Federation of European Biochemical Societies.

Comments

Archived as published. Open access.

Recommended Citation

Witkowski, Sarah; Lovering, Richard M.; and Spangenburg, Espen E., "High-Frequency Electrically Stimulated Skeletal Muscle Contractions Increase p70^s6k Phosphorylation Independent of Known IGF-I Sensitive Signaling Pathways" (2010). Exercise and Sport Studies: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/ess_facpubs/21