Insulin-like growth factor (IGF-I) is hypothesized to be a critical upstream regulator of mammalian target of rapamycin (mTOR)-regulated protein synthesis with muscle contraction. We utilized a mouse model that expresses a skeletal muscle specific dominant-negative IGF-I receptor to investigate the role of IGF-I signaling of protein synthesis in response to unilateral lengthening contractions (10 sets, 6 repetitions, 100. Hz) at 0 and 3. h following the stimulus. Our results indicate that one session of high frequency muscle contractions can activate mTOR signaling independent of signaling components directly downstream of the receptor.
Hypertrophy, IGF-I receptor mutant mouse, Insulin-like growth factor I
© 2010 Federation of European Biochemical Societies.
Witkowski, Sarah; Lovering, Richard M.; and Spangenburg, Espen E., "High-Frequency Electrically Stimulated Skeletal Muscle Contractions Increase p70s6k Phosphorylation Independent of Known IGF-I Sensitive Signaling Pathways" (2010). Exercise and Sport Studies: Faculty Publications, Smith College, Northampton, MA.