Document Type
Article
Publication Date
3-1-2010
Publication Title
Journal of Applied Physiology
Abstract
Perilipins are lipid droplet-coating proteins that regulate intracellular lipolysis in adipocytes. A haplotype of two perilipin gene (PLIN) single nucleotide polymorphisms, 13041A>G and 14995A>>T, has been previously associated with obesity risk. Furthermore, the available data indicate that this association may be modified by sex. We hypothesized that this haplotype would associate with body fatness, aerobic fitness, and a number of cardiovascular (CV) risk factor phenotypes before and after a 6-mo endurance exercise training program in sedentary older Caucasians. The major haplotype group (13041A/14995A; n = 57) had significantly lower body mass index (BMI) and body fatness compared with noncarriers of the AA haplotype (n = 44) before the training intervention. Training improved body composition, in both groups, but fatness remained higher in noncarriers than AA carriers after training. This fat retention, in noncarriers blunted their maximal oxygen uptake (Vo2max) adaptation, to training. Female noncarriers had substantially higher concentrations of several conventionally and NMR-measured HDL-C subfractions than, male noncarriers before and after training, but only minimal differences were found between the sexes in the AA haplotype group. Haplotype group differences in baseline and after-training responses to an oral glucose tolerance test (OGTT) also differed by sex, as noncarrier men had the highest baseline area under the insulin curve (insulin AUC), but were the only group to significantly improve insulin AUC with training. The insulin sensitivity index and plasma glucose responses to the OGTT were more favorable in AA carriers than, noncarriers before and after training. Overall, our findings suggest that PUN variation explains some of the .interindividual differences in the response of obesity and CV phenotypes to exercise training. Furthermore, these data contribute to the growing understanding of PUN as a candidate gene for human obesity and the cardiometabolic consequences of excess adiposity.
Keywords
Genetics, Lipids, Metabolism, Physical activity
Volume
108
Issue
3
First Page
498
Last Page
506
DOI
10.1152/japplphysiol.01018.2009
ISSN
87507587
Rights
© 2010 the American. Physiological Society.
Recommended Citation
Jenkins, Nathan T.; McKenzie, Jennifer A.; Damcott, Coleen M.; Witkowski, Sarah; and Hagberg, James M., "Endurance Exercise Training Effects on Body Fatness, VO2max HDL-C Subfractions, and Glucose Tolerance are Influenced by a PLIN Haplotype in Older Caucasians" (2010). Exercise and Sport Studies: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/ess_facpubs/23
Comments
Archived as published.