Circadian Biology and the Neurovascular Unit

Authors

• Wenlu Li, Harvard Medical School
• Steffen Tiedt, Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA)
• Jennifer H. Lawrence, Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA)
• Mary E. Harrington, Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA)Follow
• Erik S. Musiek, Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA)
• Eng H. Lo, Harvard Medical School

Document Type

Article

Publication Date

3-15-2024

Publication Title

Circulation Research

Abstract

Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology may influence the neurovascular unit. We examine how circadian clocks may operate in neural, glial, and vascular compartments, review how circadian mechanisms regulate cell-cell signaling, assess interactions with aging and vascular comorbidities, and finally ask whether and how circadian effects and disruptions in rhythms may influence the risk and progression of pathophysiology in cerebrovascular disease. Overcoming identified challenges and leveraging opportunities for future research might support the development of novel circadian-based treatments for stroke.

Keywords

aging, central nervous system, cerebrovascular disorders, circadian clocks, stroke

Volume

134

Issue

6

First Page

748

Last Page

769

DOI

10.1161/CIRCRESAHA.124.323514

ISSN

00097330

Recommended Citation

Li, Wenlu; Tiedt, Steffen; Lawrence, Jennifer H.; Harrington, Mary E.; Musiek, Erik S.; and Lo, Eng H., "Circadian Biology and the Neurovascular Unit" (2024). Neuroscience: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/nsc_facpubs/163