Document Type
Article
Publication Date
4-1-2022
Publication Title
International Journal of Molecular Sciences
Abstract
Recent studies have shed light on the diverse and complex roles of G-protein coupled receptors (GPCRs) in the pathophysiology of stroke. These receptors constitute a large family of seven transmembrane-spanning proteins that play an intricate role in cellular communication mechanisms which drive both tissue injury and repair following ischemic stroke. Orphan GPCRs represent a unique sub-class of GPCRs for which no natural ligands have been found. Interestingly, the majority of these receptors are expressed within the central nervous system where they represent a largely untapped resource for the treatment of neurological diseases. The focus of this review will thus be on the emerging roles of two brain-expressed orphan GPCRs, GPR37 and GPR37 L1, in regulating various cellular and molecular processes underlying ischemic stroke.
Keywords
astrocytes, gliosis, GPR37, GPR37 L1, inflammation, ischemic stroke, microglia, NPC
Volume
23
Issue
7
DOI
10.3390/ijms23074028
ISSN
16616596
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Rights
© 2022 by the authors.
Recommended Citation
Mouhi, Sabra; Martin, Breona; and Owino, Sharon, "Emerging Roles for the Orphan Gpcrs, Gpr37 And Gpr37 L1, in Stroke Pathophysiology" (2022). Neuroscience: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/nsc_facpubs/52
Comments
Archived as published.