International Journal of Molecular Sciences
Recent studies have shed light on the diverse and complex roles of G-protein coupled receptors (GPCRs) in the pathophysiology of stroke. These receptors constitute a large family of seven transmembrane-spanning proteins that play an intricate role in cellular communication mechanisms which drive both tissue injury and repair following ischemic stroke. Orphan GPCRs represent a unique sub-class of GPCRs for which no natural ligands have been found. Interestingly, the majority of these receptors are expressed within the central nervous system where they represent a largely untapped resource for the treatment of neurological diseases. The focus of this review will thus be on the emerging roles of two brain-expressed orphan GPCRs, GPR37 and GPR37 L1, in regulating various cellular and molecular processes underlying ischemic stroke.
astrocytes, gliosis, GPR37, GPR37 L1, inflammation, ischemic stroke, microglia, NPC
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© 2022 by the authors.
Mouhi, Sabra; Martin, Breona; and Owino, Sharon, "Emerging Roles for the Orphan Gpcrs, Gpr37 And Gpr37 L1, in Stroke Pathophysiology" (2022). Neuroscience: Faculty Publications, Smith College, Northampton, MA.