The Great Escape: Phosphorylation of Ena/VASP by PKA Promotes Filopodial Formation

Authors

Timothy M. Gomez, University of Wisconsin School of Medicine and Public Health
Estuardo Robles, University of Wisconsin School of Medicine and Public HealthFollow

Document Type

Article

Publication Date

4-8-2004

Publication Title

Neuron

Abstract

The Ena/VASP family of proteins consists of adaptor molecules that localize to subcellular sites of actin polymerization. The role of Ena/VASP proteins in the regulation of cell motility and axon outgrowth has been controversial. Recently, these proteins have been proposed to function as "anticapping" factors, which may have differential effects on filopodial versus lammelipodial actin-based protrusions. A study by Lebrand et al. in this issue of Neuron supports this model and identifies PKA as a key regulator of Ena/VASP function downstream of the chemoattractant Netrin.

Volume

42

Issue

1

First Page

1

Last Page

3

DOI

10.1016/S0896-6273(04)00188-6

ISSN

08966273

Comments

Archived as published. Open access article.

Recommended Citation

Gomez, Timothy M. and Robles, Estuardo, "The Great Escape: Phosphorylation of Ena/VASP by PKA Promotes Filopodial Formation" (2004). Neuroscience: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/nsc_facpubs/76