Author ORCID Identifier
Gillian Coughlan: 0000-0003-1806-702X
Preston P. Thakral: 0000-0001-6603-6186
Document Type
Article
Publication Date
3-15-2023
Publication Title
Cerebral Cortex
Abstract
Transcranial magnetic stimulation (TMS) delivered to the angular gyrus (AG) affects hippocampal function and associated behaviors (Thakral PP, Madore KP, Kalinowski SE, Schacter DL. Modulation of hippocampal brain networks produces changes in episodic simulation and divergent thinking. 2020a. Proc Natl Acad Sci U S A. 117:12729-12740). Here, we examine if functional magnetic resonance imaging (fMRI)-guided TMS disrupts the gradient organization of temporal signal properties, known as the temporal organization, in the hippocampus (HPC) and entorhinal cortex (ERC). For each of 2 TMS sessions, TMS was applied to either a control site (vertex) or to a left AG target region (N = 18; 14 females). Behavioral measures were then administered, and resting-state scans were acquired. Temporal dynamics were measured by tracking change in the fMRI signal (i) "within"single voxels over time, termed single-voxel autocorrelation and (ii) "between"different voxels over time, termed intervoxel similarity. TMS reduced AG connectivity with the hippocampal target and induced more rapid shifting of activity in single voxels between successive time points, lowering the single-voxel autocorrelation, within the left anteromedial HPC and posteromedial ERC. Intervoxel similarity was only marginally affected by TMS. Our findings suggest that hippocampal-targeted TMS disrupts the functional properties of the target site along the anterior/posterior axis. Further studies should examine the consequences of altering the temporal dynamics of these medial temporal areas to the successful processing of episodic information under task demand.
Keywords
angular gyrus, functional connectivity, hippocampus, intervoxel and intravoxel pattern analysis, TMS
Volume
33
Issue
6
First Page
3255
Last Page
3264
DOI
10.1093/cercor/bhac273
ISSN
10473211
Rights
© Crown copyright 2022. This article contains public sector information licensed under the Open Government Licence v3.0 (https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).
Recommended Citation
Coughlan, Gillian; Bouffard, Nichole R.; Golestani, Ali; Thakral, Preston P.; Schacter, Daniel L.; Grady, Cheryl; and Moscovitch, Morris, "Transcranial Magnetic Stimulation to the Angular Gyrus Modulates the Temporal Dynamics of the Hippocampus and Entorhinal Cortex" (2023). Psychology: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/psy_facpubs/241
Comments
Archived as published.