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Publication Date
2025-5
First Advisor
Stylianos P. Scordilis
Document Type
Honors Project
Degree Name
Bachelor of Arts
Department
Biochemistry
Keywords
STAT3, muscle, myogenesis, alantolactone, cachexia, myokines, IL6, myogenic regulatory factors, C2C12, myoblasts, skeletal muscle, myocytes, proteomics, immunoblotting, immunofluorescence
Abstract
Skeletal muscle is a plastic tissue continuously being remodeled and repaired. Imbalances in muscle homeostasis are implicated in muscle wasting as a complication of age and disease, which worsens prognoses and quality of life. A common signaling pathway has been identified for its roles in embryonic development, cachexic wasting, and exercise-induced hypertrophy. STAT3 is a transcription factor activated by cytokines that positively controls pathways responsible for muscle cell proliferation, differentiation, proteolysis, and catabolism. Inhibitors of STAT3 phosphorylation have potential as disease-modifying drugs in cancer-associated cachexia. However, it is essential to elucidate the paradoxical role of STAT3 in apparently opposing processes within the development of muscle tissue.
Rights
©2025 Lucy Glueck. Access limited to the Smith College community and other researchers while on campus. Smith College community members also may access from off-campus using a Smith College log-in. Other off-campus researchers may request a copy through Interlibrary Loan for personal use.
Language
English
Recommended Citation
Glueck, Lucy, "The Effects of STAT3 Inhibitors on Myoblast Proliferation and Differentiation" (2025). Honors Project, Smith College, Northampton, MA.
https://scholarworks.smith.edu/theses/2744
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Comments
81 pages: color illustrations. Includes bibliographical references (pages 76-81).