Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides

Authors

Fubin Song, Smith College
So Hyun Park, Smith College
Christine Wu, Smith College
Alexandra E. Strom, Smith CollegeFollow

Document Type

Article

Publication Date

3-3-2023

Publication Title

Journal of Organic Chemistry

Abstract

We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates.

Volume

88

Issue

5

First Page

3353

Last Page

3358

DOI

10.1021/acs.joc.3c00210

ISSN

00223263

Rights

© 2023 The Authors.

Comments

Archived as published

Recommended Citation

Song, Fubin; Park, So Hyun; Wu, Christine; and Strom, Alexandra E., "Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides" (2023). Chemistry: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/chm_facpubs/76