Journal of Organic Chemistry
We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates.
© 2023 The Authors.
Song, Fubin; Park, So Hyun; Wu, Christine; and Strom, Alexandra E., "Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides" (2023). Chemistry: Faculty Publications, Smith College, Northampton, MA.