Document Type
Article
Publication Date
9-6-2013
Publication Title
Journal of Organic Chemistry
Abstract
A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.
Volume
78
Issue
17
First Page
8909
Last Page
8914
ISSN
00223263
Version
Author's Accepted Manuscript
Recommended Citation
Strom, Alexandra E. and Hartwig, John F., "One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination" (2013). Chemistry: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/chm_facpubs/82