One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination

Authors

Alexandra E. Strom, Stanford UniversityFollow
John F. Hartwig, University of California, Berkeley

Document Type

Article

Publication Date

9-6-2013

Publication Title

Journal of Organic Chemistry

Abstract

A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.

Volume

78

Issue

17

First Page

8909

Last Page

8914

DOI

10.1021/jo401498w

ISSN

00223263

Comments

Peer reviewed accepted manuscript.

Recommended Citation

Strom, Alexandra E. and Hartwig, John F., "One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination" (2013). Chemistry: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/chm_facpubs/82