Document Type
Article
Publication Date
5-1-2019
Publication Title
Menopause
Abstract
Objective:The aim of the study was to evaluate if there are differences in endothelial function before and after acute exercise in women at different menopausal stages with high and low cardiorespiratory fitness.Methods:Participants were healthy high-fit premenopausal (n = 11), perimenopausal (n = 12), and postmenopausal women (n = 13) and low-fit perimenopausal (n = 7) and postmenopausal women (n = 8). Brachial artery flow-mediated dilation (FMD) was measured before and after acute moderate intensity exercise. FMD was calculated as (Diameterpeak-Diameterbaseline)/ Diameterbaseline) × 100. Differences between high-fit women and between high- and low-fit perimenopausal and postmenopausal women were assessed with repeated-measure ANOVAs. Relations with FMD were assessed with Pearson correlations.Results:FMD was reduced with progressive menopausal stage in high-fit women (P = 0.005) and was lower in perimenopausal compared to postmenopausal women (P = 0.047). FMD was lower in high-fit compared to low-fit women (P = 0.006) and there was no relation between FMD and VO2peak (P > 0.05). There was an inverse relation between FMD and follicle-stimulating hormone (P < 0.05), but not estradiol (P > 0.05).Conclusions:These data suggest that endothelial function is lower with progressive menopausal stage in women with high cardiorespiratory fitness; that FMD is lower in women with higher cardiorespiratory fitness; and that FSH, but not estradiol, is associated with FMD.
Keywords
Acute exercise, Cardiorespiratory fitness, Endothelial function, Flow-mediated dilation, Follicle-stimulating hormone, Menopause
Volume
26
Issue
5
First Page
531
Last Page
539
DOI
10.1097/GME.0000000000001267
ISSN
10723714
Recommended Citation
Serviente, Corinna and Witkowski, Sarah, "Follicle-Stimulating Hormone, but not Cardiorespiratory Fitness, is Associated with Flow-Mediated Dilation with Advancing Menopausal Stage" (2019). Exercise and Sport Studies: Faculty Publications, Smith College, Northampton, MA.
https://scholarworks.smith.edu/ess_facpubs/10
Comments
Peer reviewed accepted manuscript.